NEW YORK • For people sheltering at home because of the coronavirus and unable to visit the gym or otherwise weight train, a new study of the inner workings of the muscles should be heartening.
It finds that if muscles have been trained in the past, they seem to develop a molecular memory of working out that lingers through a prolonged period of inactivity. Once people start training again, this "muscle memory" could speed the process by which they regain their former muscular strength and size.
The findings suggest, in effect, that skipping workouts now need not guarantee enfeeblement later, and if people forget what fitness once felt like, their muscles recollect.
Many people probably think that muscle memory refers to the well-documented ability to retain physical skills even without practice.
Learn to ride a bicycle and you never forget. Ditto, by and large, for hitting a free throw, skiing a mogul or starting to walk as a child.
These repeated movements apparently burn themselves into people's motor neurons, scientists believe, and remain available for later retrieval from their brains and nervous systems, whenever needed.
But it has been less clear whether trace memories of past exercise reside within the muscles themselves and affect how well people respond to future workouts.
Past studies in animals and people suggest that they might.
In a representative recent study, for instance, sedentary older men who completed 12 weeks of weight training gained muscle strength and size, much of which they lost during a subsequent 12-week layoff, but all of which returned within only eight weeks of returning to the gym.
How past exercise primes the muscles for future gains has not been clear, though.
In animal experiments, muscle cells in mice and rats develop extra nuclei when the animals train, and these specialised bits of the cell remain even if the animals stop training and lounge about.
The added nuclei are thought to prepare the muscles to add strength and size rapidly when the animals return to working out.
But a few small experiments with people suggest that humans' muscle cells may not pack on extra nuclei when they lift weights.
So, a group of Swedish researchers began to wonder recently whether alterations in the activity of genes and proteins inside the muscles might help to explain whether and why the muscles remember how to be strong.
To find out, they began by recruiting 19 young men and women who had never played sports or formally exercised at all, so that their muscles were new to formal weight training.
They checked these volunteers' current muscular strength and size, and then had them start training a single leg.
To accomplish this, the young men and women completed increasingly strenuous leg presses and leg extensions using only their right or left leg, while the other limb lollygagged to the side.
These one-legged workouts continued for 10 weeks, at which point the researchers remeasured muscles, and then the volunteers stopped their training completely for 20 weeks.
After this layoff from working out, they returned to the laboratory, where the scientists checked the current state of their leg muscles, took muscle biopsies from both legs and had them complete a strenuous leg workout, using both legs this time.
Afterwards, the researchers biopsied the muscles again. Then they checked the levels of a wide array of gene markers and biochemical signals within the volunteers' muscle cells that are believed to be related to muscle health and growth.
They found telling differences between the legs that had trained and those that had not, both before and after the lone training session.
For one thing, the previously trained leg remained sturdier, having retained about 50 per cent of its strength gains during the 20 wRead More – Source