Hundreds of demonstrators took to the streets in Kyiv in protest against mandatory vaccination and new restrictions for non-vaccinated residents.
Protesters carried placards reading “no to genocide of Ukrainians” and “say ‘no’ to lies”.
Some were also demanding the release of anti-vaccine activist Ostap Stakhiv, who caught arrested in the city of Lviv last week for undermining public health through alleged links with Russia.
Mr Stakhiv has denied all the allegations against him.
Ukraine, which has recently seen a rise in vaccination numbers after imposing restrictions in public places, is still struggling to persuade many of its citizens who remain hesitant to receive their shots.
The country is experiencing a new surge in coronavirus cases as the highly transmissible Delta variant sweeps across Europe.
Ukraine today reported 14,325 new daily Covid cases and 595 coronavirus-related deaths.
Europe is expected to record 2 million Covid deaths by March next year, the World Health Organization (WHO) has warned.
The international agency further said that the pandemic had become the number one cause of death in the region.
Deaths further reported an increase to nearly 4,200 a day, double the number reported in September.
Describing the situation as “very serious”, the WHO said it expected “high or extreme stress” on hospital beds in 25 of the region’s 53 countries.
Intensive care units in 49 countries set to come under similar strain, according to the WHO.
The warning comes as several nations report record-high infection rates and introduce full and partial lockdowns.